Surprising outcomes on weight reduction and breast most cancers from worldwide research

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New research in the February 2021 issue of JNCCN – Journal of the National Comprehensive Cancer Network examined body mass index (BMI) data for people with HER2-positive early-stage breast cancer and found that patients over two years of age had weight loss of 5% was associated with poorer results. Weight gain over the same period had no effect on survival rates.

“The finding that weight loss, not weight gain, was associated with worse results is unexpected,” said lead researcher Samuel Martel, MD, Universitè de Sherbrooke, Quebec, Canada, who worked with researchers in Belgium, Brazil, Germany, Italy. Switzerland and the United Kingdom, and the National Cancer Institute and Mayo Clinic in the United States. “We could not distinguish between intentional and unintentional weight loss, so it is a matter of speculation whether worse results are due to weight loss or vice versa. We hope our results underscore the importance of including consecutive and prolonged data collection on weight.” in oncological studies and a better understanding of the metabolic processes after cancer diagnosis, which can affect the results. “

The BMI data comes from the ALTTO BIG 2-06 study, which collected height and weight data from 8,381 patients with HER2-positive early-stage breast cancer treated with chemotherapy plus trastuzumab and / or lapatinib. 2.2% were underweight at the start of treatment, 45.3% were of normal weight, 32.1% were classified as overweight, another 20.4% were obese – defined as having a BMI greater than 30. Initial obesity was with poorer results including more common and more serious adverse events leading to discontinuation of treatment and significantly poorer overall survival rates.

“It was surprising to see that greater than 5% weight loss after 2 years was associated with poorer distance disease-free survival. Is our general advice to obese / overweight patients to exercise and lose weight wrong?” interviewed Anthony D. Elias, MD, University of Colorado Cancer Center, member of the NCCN Panel on Clinical Practice Guidelines (NCCN Guidelines) for Breast Cancer. “Careful examination of the Kaplan-Meier hazard charts suggests that the relapse curves for those with weight loss are steeper in the second and third years of follow-up, but relatively parallel thereafter. It is possible that the weight loss observed early is an indication of an impending relapse of breast cancer. “

The study highlights the importance of weight management for cancer survival. The authors hope that their results will form the basis for further research and oncology studies to guide weight control during survival.

Large study links persistent weight loss with reduced risk of breast cancer

More information:
Samuel Martel et al., Body Mass Index and Weight Change in Patients with HER2-Positive Early Breast Cancer: Exploratory Analysis of the ALTTO BIG 2-06 Study, Journal of the National Comprehensive Cancer Network (2021). DOI: 10.6004 / jnccn.2020.7606

Provided by the National Comprehensive Cancer Network

Quote: Unexpected results on weight loss and breast cancer from an international study (2021, February 16), accessed on February 21, 2021 from https://medicalxpress.com/news/2021-02-unexpected-weight-loss-breast-cancer. html

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